Pipettes and suction heads are very important for accurate quantification of experimental samples, both in routine experiments and in current COVID-19 detection and diagnosis. In addition to accurate quantification, the suction heads we use also need to meet standards to ensure that the samples are not contaminated. Especially now, the section on manufacturing raw materials (plasmid DNA, etc.) will mention pyrogen (test for bacterial endotoxins), production process control (virus harvesting, sample extraction/purification, etc.). And characteristic analysis (pollutant analysis, etc.), not to mention biological pollutants in general.

For the body, endotoxins can induce endogenous pyrogen, such as tumor necrosis factor, interleukin, 2-interferon, etc. And stimulates thermoregulation, leading to fever disorders and possible shock or death. In addition, endotoxin is difficult to eliminate, ordinary 121 autoclave can not remove. It can only be completely destroyed at a high temperature of more than 160 for 2~4h. Therefore, pyrogen contamination should be avoided in the manufacturing and production process of biotherapeutic products to ensure the safety of therapeutic products. The experimental instruments used in the production process should not only ensure that the raw and auxiliary materials of biotherapy products are pyrogen free, but also ensure that exogenous pyrogen and other biological pollutants will not be introduced.

Especially often used pipette suction head, if the production environment of the suction head is not up to standard, there will be dust; Or human contact during manufacturing, such as manually inserting the box suction, may cause the suction to contain a heat source. Direct contact between the suction head and the sample can cause heat to enter the sample, affect the safety of therapeutic products, and even threaten the life of patients. Therefore, the production of biotherapy products needs to choose pyrogen free suction head!